Products for preclinical and translational biomedical research
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Quickly find MCAO sutures using search function
If you have a catalog number in mind, you can quickly search the product out by using the search function. The more information you type into the search box, the narrower product list will be search out. For examples, typing in “40’ will pullout all the products that contain a “40” in their catalog numbers; typing in “35” will pullout all the products that contain a “35” in their catalog numbers; typing in “4035” will only pull out the products that contain both a “40” and a “35” in their catalog numbers.
Which MCAO suture should be the correct one for my study?
The answer to this question could be very complicated, and it may need a pilot study for determining the optimal MCAO sutures. You may find some information in the literature that used a similar method for inducing MCAO model as that will be in your study. For your reference and convenience, we composed the following chart for an initial tryout of MCAO sutures. Ask Doccol if you cannot determine the monofilaments for your study.
|
Animal Body Weight (g) |
Suggested Diameters (mm) |
Bare filament USP “0” # |
Available Coating |
Search For |
|
12-15 |
0.15, 0.17 |
8-0, 7-0 |
2-10 |
“015”, “017” |
|
15-20 |
0.17, 0.19 |
8-0, 7-0 |
2-10 |
“017”, “019” |
|
21-25 |
0.21, 0.22 |
8-0, 7-0, 6-0 |
2-10 |
"021", “022” |
|
26-30 |
0.22, 0.23 |
8-0, 7-0, 6-0 |
2-10 |
"022", “023” |
|
31-35 |
0.23 |
8-0, 7-0, 6-0 |
2-10 |
"023" |
|
36-200 |
0.24, 0.25, 0.27, 0.29, 0.31,0.33 |
5-0, 6-0 |
2-10* |
"024", “025”, "027", |
|
201-250 |
0.33, 0.35 |
5-0, 4-0 |
2-10* |
“033”, “035” |
|
251-280 |
0.35, 0.37 |
5-0, 4-0 |
2-10* |
“035”, “037” |
|
281-330 |
0.37, 0.39 |
5-0, 4-0 |
2-10* |
“037”, “039” |
|
331-400 |
0.41 |
4-0, 3-0 |
2-10 |
“041” |
|
401-500 |
0.43, 0.45 |
4-0, 3-0 |
2-10 |
“043", "045", "047" |
|
501-600 |
0.47, 0.49 |
4-0, 3-0 |
2-10 |
“047", "049" |
|
601-700 |
0.51 |
3-0 |
5-7 |
“051" |
|
701-800 |
0.54 |
3-0 |
5-7 |
“054" |
|
801-900 |
0.54 |
3-0 |
5-7 |
“054" |
|
901-1000 |
0.58 |
3-0 |
5-6 |
“058" |
Up to 10-15 mm coating length may be possible, please contact Doccol to check its availability.
Coating lengths are available from 1-2 mm to 9-10 mm. A super long coating length from 10 mm to 15 mm may also be possible through special request to Doccol. The most commonly purchased MCAO sutures have coating lengths of 5-6 mm and 4-5 mm. A shorter coating length leaves more bare surface area on the MCAO suture, which makes the surgeon feel easier to handle it. However, a shorter coating length may increase the chance of incomplete occlusion in inexperienced hands. If the coated part of the MCAO suture passes over the origin of MCA, the blood from the posterior circulation may reach MCA through the residue space around the uncoated part of the MCAO suture. A longer coating length may increase the chance of complete occlusion; however, its increased contacting area with endothelial cells may cause more traction force on those contacted endothelial cells. Such traction may cause endothelial cell damage when you withdraw the MCAO suture for reperfusion. In a summary, a shorter length may be good for reperfusion while longer length good for permanent occlusion; and the selection of the coating length will depend on your own study design, lab setting, and your surgical skill.
Regular monofilaments are designed for just one time use for most common experiments, and are not recommended for repeated use. Reusable MCAO sutures are specially designed and manufactured such that they have a more uniformed coating surface and a more rigid bare filament, which make them maintaining their shapes better after their initial use than the disposable ones do. They are designed to use twice and may be ideal for the in vivo efficacy study by using paired-controls, in which the paired animals have the same body weight and use the same monofilament. Such a use of paired-controls may drastically increase the consistence of infarction volume. In a catalog number “Re” stands for reusable.
The catalog numbers of MCAO sutures on doccol.com
In order to select MCAO sutures on Doccol website, you should have in mind of the filament size, diameter, and coating length of your MCAO sutures to be purchased. Doccol MCAO sutures are encoded in a formala of "U0DDLL(L)PKN(N)(Re)" according to suture size, coating diameter, coating length, pack size and reusability, wherein "U0" stands for USP “0” number, "DD" for tip (coated part) diameter in "0.DD mm", "LL(L)" for coating length in "L-L(L) mm", "PKN(N)" for pack of "N(N) filaments", "Re" for reusable sutures, and "()" for optional. For example, "7019910PK5Re" stands for "made of 7-0 bare suture, coated tip diameter 0.19 mm, coating length 9-10 mm, pack of 5 filaments, reusable". You may check with the following chart for a near complete list of MCAO sutures. Please use these information to locate your MCAO sutures, and further verify the product descriptions to ensure that you have selected the correct products. Please don't hesitate to contact Doccol if you need to customize your MCAO sutures.
Replacement for some obsolete catalog numbers:
7023910PK5Re = 702309PK5Re, 70CL9TD023Re, 70-1720ReL10
702356PK5Re = 7023PK5Re, 70-1720PK5Re
602356PK10 = 6023PK10, 60-1720PK10
602356PK5Re = 6023PK5Re, 60-1720PK5Re
503356PK10 = 5033PK10, 50-3033PK10
403756PK10 = 4037PK10, 40-3033PK10
Others available upon request: 403723PK10-TL40, 304967PK10, 304967PK5Re, 305467PK10, 305167PK10, 304767PK10, 404767PK10, 503967PK10
Please click this link for the catalog table of Doccol MCAO sutures.